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Book Cruises To South America From San Diego California Online And Save

Cruisebound

Azamara

35 Night Grand Voyage Cruise aboard the Azamara Quest departing from San Diego, California, on 2027-05-24, cruises to Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Aqaba, Jordan, Puntarenas, Costa Rica, Panama Canal, Panama, Cartagena, Colombia, Cartagena, Colombia, Miami, Florida, New York, New York, Newport, Rhode Island, Cape Cod, Massachusetts, Boston, Massachusetts, Halifax, Nova Scotia, Cruz Bay, St. John, U.S. Virgin Islands, Cobh (Cork), Ireland, Cobh (Cork), Ireland, Plymouth, England, Le Havre (Paris), France and Tilbury (London), England, starting at 8409.0 per person.

35 Night Grand Voyage Cruise

17 Night South America Cruise aboard the Azamara Quest departing from San Diego, California, on 2027-05-24, cruises to Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Aqaba, Jordan, Puntarenas, Costa Rica, Panama Canal, Panama, Cartagena, Colombia, Cartagena, Colombia and Miami, Florida, starting at 4569.0 per person.

17 Night South America Cruise

Disney Cruise Line

14 Night Panama Canal Cruise aboard the Disney Magic departing from San Diego, California, on 2026-11-06, cruises to Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Panama City, Panama, Cartagena, Colombia, Georgetown, Grand Cayman, Cayman Islands and Galveston, Texas, starting at 2366.0 per person.

14 Night Panama Canal Cruise

Holland America Line

26 Night Panama Canal Cruise aboard the Zuiderdam departing from San Diego, California, on 2026-02-27, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Panama Canal, Panama, Fuerte Amador, Panama, Cartagena, Colombia, Half Moon Cay (Little San Salvador Island), Bahamas, Miami, Florida, Philipsburg, St. Maarten, St. John's, Antigua, Fort-de-France, Martinique, Roseau, Dominica, Port of Basseterre, St. Kitts, St. Kitts and Nevis, St. Thomas, U.S. Virgin Islands, Half Moon Cay (Little San Salvador Island), Bahamas and Miami, Florida, starting at 2199.0 per person.

26 Night Panama Canal Cruise

27 Night Panama Canal Cruise aboard the Zuiderdam departing from San Diego, California, on 2026-02-15, cruises to Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Guaymas Sonora Mexico, Toplobampo, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Fuerte Amador, Panama, Panama Canal, Panama, Cartagena, Colombia, Half Moon Cay (Little San Salvador Island), Bahamas and Miami, Florida, starting at 2154.0 per person.

27 Night Panama Canal Cruise

14 Night World Cruise aboard the Volendam departing from San Diego, California, on 2026-05-03, cruises to Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Panama Canal, Panama, Fuerte Amador, Panama, Cartagena, Colombia and Fort Lauderdale (Port Everglades), Florida, starting at 2039.0 per person.

14 Night World Cruise

16 Night Panama Canal Cruise aboard the Nieuw Amsterdam departing from San Diego, California, on 2026-10-02, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Panama Canal, Panama, Cartagena, Colombia, Relaxaway Half Moon Cay, Bahamas and Fort Lauderdale (Port Everglades), Florida, starting at 1759.0 per person.

16 Night Panama Canal Cruise

Norwegian Cruise Line

15 Night Repo aboard the Norwegian Star departing from San Diego, California, on 2027-04-03, cruises to Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal, Panama, Cartagena, Colombia and Miami, Florida, starting at 1569.0 per person.

15 Night Repo

15 Night Panama Canal-Panama City aboard the Norwegian Jade departing from San Diego, California, on 2026-02-12, cruises to Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal, Panama, Cartagena, Colombia and Miami, Florida, starting at 1459.25 per person.

15 Night Panama Canal-Panama City

15 Night Panama Canal Cruise aboard the Zuiderdam departing from San Diego, California, on 2026-02-27, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Fuerte Amador, Panama, Panama Canal, Panama, Cartagena, Colombia, Half Moon Cay (Little San Salvador Island), Bahamas and Miami, Florida, starting at 1004.0 per person.

15 Night Panama Canal Cruise

Popular Sailings

Royal Caribbean International

Browse Cruise Lines

Zuiderdam

Azamara Quest

Volendam

Zaandam

Norwegian Jade

Browse Cruise Ships

San Diego, California

Cabo San Lucas, Mexico

Acapulco, Mexico

Puerto Quetzal, Guatemala

Aqaba, Jordan

Puntarenas, Costa Rica

Panama Canal, Panama

Cartagena, Colombia

Miami, Florida

New York, New York

Newport, Rhode Island

Cape Cod, Massachusetts

Boston, Massachusetts

Halifax, Nova Scotia

Cruz Bay, St. John, U.S. Virgin Islands

Cobh (Cork), Ireland

Plymouth, England

Le Havre (Paris), France

Tilbury (London), England

Puerto Vallarta, Mexico

Panama City, Panama

Georgetown, Grand Cayman, Cayman Islands

Galveston, Texas

Disney Magic

San Diego, California, Us (boarding Time To Be Assigned)

Huatulco, Mexico

Puerto Chiapas, Mexico (times Subject To Tidal Cond)

Puerto Chiapas, Mexico

Fuerte Amador, Panama (overnight Times Subject To Canal Transit)

Fuerte Amador, Panama

Enter Panama Canal Balboa (cruising Only Transit Times Are Approximate)

Fuerte Amador, Panama (times Subject To Canal Transit)

Half Moon Cay, Bahamas (tender Required Wheelchair Access Limited)

Half Moon Cay (Little San Salvador Island), Bahamas

Philipsburg, St. Maarten

St. John's, Antigua

Fort-de-france, Martinique (passport Required)

Fort-de-France, Martinique

Roseau, Dominica

Basseterre, St Kitts And Nevis (tender Required Wheelchair Access Limited)

Port of Basseterre, St. Kitts, St. Kitts and Nevis

St. Thomas, U.S. Virgin Islands

Cabo San Lucas, Mexico (tender Required Wheelchair Access Limited)

Pichilingue (La Paz), Mexico

Loreto, Mexico (tender Required Wheelchair Access Limited)

Loreto, Mexico

Guaymas Sonora Mexico

Toplobampo, Mexico

Mazatlan, Mexico

Ensenada, Mexico

Manzanillo, Mexico

Acajutla, El Salvador

Fort Lauderdale (Port Everglades), Florida

Relaxaway Half Moon Cay, Bahamas

Nieuw Amsterdam

Norwegian Star

San Diego, California, Us Boarding Time To Be Assigned

Puerto Chiapas, Mexico Times Subject To Tidal Cond

Fuerte Amador, Panama Overnight Times Subject To Canal Transit

Fuerte Amador, Panama Times Subject To Canal Transit

Half Moon Cay, Bahamas Tender Required Wheelchair Access Limited