Find and compare cruises from Palermo, Sicily, Italy in October with MSC Cruises. Get cruise deals, including last-minute deals.

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23 Night Mediterranean Cruise aboard the MSC Seaside departing from Palermo, Sicily, Italy, on 2025-10-24, cruises to Naples, Italy, Livorno (Florence/Pisa), Italy, Marseille, France, Barcelona, Spain, Valencia, Spain, Casablanca, Morocco, Bridgetown, Barbados, St. Georges, Grenada, West Indies, Philipsburg, St. Maarten, San Juan, Puerto Rico and Miami, Florida, starting at 1449.0 per person.

23 Night Mediterranean Cruise

7 Night Mediterranean - Western Cruise aboard the MSC Grandiosa departing from Palermo, Sicily, Italy, on 2025-10-20, cruises to Ibiza, Spain, Valencia, Spain, Marseille, France, Genoa, Italy and Civitavecchia (Rome), Italy, starting at 879.0 per person.

7 Night Mediterranean - Western Cruise

7 Night Mediterranean - Western Cruise aboard the MSC Grandiosa departing from Palermo, Sicily, Italy, on 2025-10-27, cruises to Ibiza, Spain, Valencia, Spain, Marseille, France, Genoa, Italy and Civitavecchia (Rome), Italy, starting at 843.0 per person.

3 Night Mediterranean - Western Cruise aboard the MSC Magnifica departing from Palermo, Sicily, Italy, on 2025-10-01, cruises to Valletta, Malta and Barcelona, Spain, starting at 429.0 per person.

3 Night Mediterranean - Western Cruise

4 Night Mediterranean - Western Cruise aboard the MSC Seaside departing from Palermo, Sicily, Italy, on 2025-10-24, cruises to Naples, Italy, Livorno (Florence/Pisa), Italy, Marseille, France and Barcelona, Spain, starting at 332.00 per person.

4 Night Mediterranean - Western Cruise

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MSC Grandiosa

MSC Magnifica

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Mediterranean

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Explore Destinations

Palermo, Sicily, Italy

Naples, Italy

Livorno (Florence/Pisa), Italy

Marseille, France

Barcelona, Spain

Valencia, Spain

Casablanca, Morocco

Bridgetown, Barbados

St. Georges, Grenada, West Indies

Philipsburg, St. Maarten

San Juan, Puerto Rico

Miami, Florida

Ibiza, Spain

Genoa, Italy

Civitavecchia (Rome), Italy

Valletta, Malta