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Book cruises from Colon, Panama in 2025 Online And Save

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12 Night Panama Canal Cruise aboard the Regatta departing from Colon, Panama, on 2025-11-14, cruises to Panama Canal Daylight Transit, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Cabo San Lucas, Mexico, Ensenada, Mexico and Los Angeles, California, starting at 2220.0 per person.

12 Night Panama Canal Cruise

7 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-11-22, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 819.5 per person.

7 Night Southern Caribbean Cruise

8 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-12, cruises to Cartagena, Colombia, Kralendijk, Bonaire, Dutch Antilles, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 1223.5 per person.

8 Night Southern Caribbean Cruise

7 Night Southern Caribbean Holiday aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-20, cruises to Cartagena, Colombia, Willemstad, Curacao and Port of Oranjestad, Aruba, Caribbean, starting at 1174.0 per person.

7 Night Southern Caribbean Holiday

6 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-06, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 711.0 per person.

6 Night Southern Caribbean Cruise

7 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-11-29, cruises to Cartagena, Colombia, Kralendijk, Bonaire, Dutch Antilles and Willemstad, Curacao, starting at 684.0 per person.

Popular Sailings

Royal Caribbean International

Oceania Cruises

Browse Cruise Lines

Central America

Panama Canal

Caribbean

South America

Pacific

Explore Destinations

Colon, Panama

Panama Canal Daylight Transit

Puntarenas, Costa Rica

Puerto Quetzal, Guatemala

Acapulco, Mexico

Cabo San Lucas, Mexico

Ensenada, Mexico

Los Angeles, California

Regatta

Cartagena, Colombia

Port of Oranjestad, Aruba, Caribbean

Willemstad, Curacao

Serenade of the Seas

Kralendijk, Bonaire, Dutch Antilles