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6 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-06, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 878.5 per person.

6 Night Southern Caribbean Cruise

7 Night Southern Caribbean Holiday aboard the Jewel of the Seas departing from Colon, Panama, on 2026-12-19, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Kralendijk, Bonaire, Dutch Antilles, starting at 921.0 per person.

7 Night Southern Caribbean Holiday

10 Night Mexico Cruise aboard the Seven Seas Grandeur departing from Panama City, Panama, on 2026-01-15, cruises to Puntarenas, Costa Rica, Puerto Corinto, Nicaragua, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Ensenada, Mexico and Los Angeles, California, starting at 7449.00 per person.

10 Night Mexico Cruise

11 Night Caribbean - Western Cruise aboard the MSC Divina departing from Miami, Florida, on 2026-03-29, cruises to Ocho Rios, Jamaica, Port of Oranjestad, Aruba, Caribbean, Cartagena, Colombia, Colon, Panama, Roatan, Honduras and Ocean Cay, Bahamas, starting at 874.0 per person.

11 Night Caribbean - Western Cruise

7 Night Southern Caribbean Cruise aboard the Jewel of the Seas departing from Colon, Panama, on 2026-09-12, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 731.5 per person.

7 Night Southern Caribbean Cruise

10 Night Classic Panama Canal Passage aboard the Viking Mars departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-10, cruises to Cozumel, Mexico, Belize City, Belize, Roatan, Honduras, Caldera (san Jose), Costa Rica, Colon, Panama, Fuerte Amador, Panama and Fuerte Amador, Panama, starting at 3149.0 per person.

10 Night Classic Panama Canal Passage

16 Night Panama Canal Eastbound Cruise aboard the Celebrity Summit departing from Los Angeles, California, on 2025-09-19, cruises to Puerto Vallarta, Mexico, Puerto Barrios, Guatemala, Puntarenas, Costa Rica, Panama Canal, Panama, Cartagena, Colombia, Falmouth, Jamaica, Georgetown, Grand Cayman, Cayman Islands and Fort Lauderdale (Port Everglades), Florida, starting at 848.0 per person.

16 Night Panama Canal Eastbound Cruise

17 Night Transcanal Cruise aboard the Ruby Princess departing from San Francisco, California, on 2026-08-31, cruises to Mazatlan, Mexico, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Cartagena, Colombia and Fort Lauderdale (Port Everglades), Florida, starting at 778.0 per person.

17 Night Transcanal Cruise

7 Night Southern Caribbean Cruise aboard the Jewel of the Seas departing from Colon, Panama, on 2026-09-19, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 731.5 per person.

11 Night Panama Canal aboard the Norwegian Jewel departing from Miami, Florida, on 2025-12-12, cruises to Georgetown, Grand Cayman, Cayman Islands, Cartagena, Colombia, Colon, Panama, Panama Canal/Gatun Lake, Panama, Puerto Limon, Costa Rica, Harvest Caye, Belize and Cozumel, Mexico, starting at 728.70000000000005 per person.

11 Night Panama Canal

Popular Sailings

 Fort Lauderdale (Port Everglades)

Colon, Panama

Cartagena, Colombia

Miami, Florida

Los Angeles

Explore Departure Ports

Royal Caribbean International

Holland America Line

Princess Cruises

Norwegian Cruise Line

Carnival Cruise Line

Browse Cruise Lines

Port of Oranjestad, Aruba, Caribbean

Willemstad, Curacao

Serenade of the Seas

Kralendijk, Bonaire, Dutch Antilles

Jewel of the Seas

Panama City, Panama

Puntarenas, Costa Rica

Puerto Corinto, Nicaragua

Puerto Vallarta, Mexico

Cabo San Lucas, Mexico

Ensenada, Mexico

Los Angeles, California

Regent Seven Seas Cruises

Seven Seas Grandeur

Ocho Rios, Jamaica

Roatan, Honduras

Ocean Cay, Bahamas

MSC Cruises

MSC Divina

Fort Lauderdale (Port Everglades), Florida

Cozumel, Mexico

Belize City, Belize

Caldera (san Jose), Costa Rica

Fuerte Amador, Panama

Viking Ocean Cruises

Viking Mars

Puerto Barrios, Guatemala

Panama Canal, Panama

Falmouth, Jamaica

Georgetown, Grand Cayman, Cayman Islands

Celebrity Cruises

Celebrity Summit

San Francisco, California

Mazatlan, Mexico

Puerto Quetzal, Guatemala

Panama Canal Full Transit New Locks

Ruby Princess

Panama Canal/Gatun Lake, Panama

Puerto Limon, Costa Rica

Harvest Caye, Belize

Norwegian Jewel

Panama Canal