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Regent Seven Seas Cruises

24 Night South America Cruise aboard the Seven Seas Splendor departing from Buenos Aires, Argentina, on 2026-02-17, cruises to Punta del Este, Uruguay, Rio Grande, Rio Grande do Sul, Brazil, Porto Belo (Santa Catarina), Brazil, Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Rio de Janeiro, Brazil, Buzios, Brazil, Bahia de Salvador, Brazil, Maceio, Brazil, Recife, Brazil, Belem, Brazil, Devils Island, French Guiana, Castries, St. Lucia, Roseau, Dominica, Philipsburg, St. Maarten and Miami, Florida, starting at 14899.0 per person.

24 Night South America Cruise

Azamara

40 Night Grand Voyage Cruise aboard the Azamara Journey departing from Buenos Aires, Argentina, on 2027-02-17, cruises to Montevideo, Uruguay, Punta del Este, Uruguay, South Orkney Islands, Antarctica, Ushuaia, Argentina, Ushuaia, Argentina, Sailing In The Beagle Channel, Punta Arenas, Chile, Puerto Chacabuco, Chile, Puerto Montt, Chile, Iles des Saintes, Guadeloupe, Coquimbo (La Serena), Chile, Iquique, Chile, Arica, Chile, Pisco (Puerto San Martin), Peru, Callao (Lima), Peru, Callao (Lima), Peru, Panama City, Panama, Panama Canal, Panama, Puerto Limon, Costa Rica, San Andres Island, Colombia, Cozumel, Mexico and Miami, Florida, starting at 12789.0 per person.

40 Night Grand Voyage Cruise

Oceania Cruises

31 Night World Cruise aboard the Oceania Marina departing from Buenos Aires, Argentina, on 2026-03-07, cruises to Montevideo, Uruguay, Punta del Este, Uruguay, Itajai, Brazil, Santos (Sao Paulo), Brazil, Paraty, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Rio de Janeiro, Brazil, Rio de Janeiro, Brazil, Rio de Janeiro, Brazil, Recife, Brazil, Alter do Chao, Brazil, Boca da Valeria, Brazil, Manaus, Brazil, Manaus, Brazil, Parintins, Brazil, Santarem, Brazil, Castries, St. Lucia, Port of Basseterre, St. Kitts, St. Kitts and Nevis and Miami, Florida, starting at 11299.0 per person.

31 Night World Cruise

33 Night World Cruise aboard the Oceania  Insignia departing from Buenos Aires, Argentina, on 2027-03-07, cruises to Montevideo, Uruguay, Punta del Este, Uruguay, Rio Grande, Rio Grande do Sul, Brazil, Florianopolis, Brazil, Itajai, Brazil, Santos (Sao Paulo), Brazil, Paraty, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Rio de Janeiro, Brazil, Rio de Janeiro, Brazil, Alter do Chao, Brazil, Boca da Valeria, Brazil, Manaus, Brazil, Manaus, Brazil, Parintins, Brazil, Santarem, Brazil, Bridgetown, Barbados, St. John's, Antigua, Charlotte Amalie, St. Thomas, U.S. Virgin Islands and Miami, Florida, starting at 9899.0 per person.

33 Night World Cruise

21 Night South America Cruise aboard the Azamara Journey departing from Buenos Aires, Argentina, on 2027-02-17, cruises to Montevideo, Uruguay, Punta del Este, Uruguay, South Orkney Islands, Antarctica, Ushuaia, Argentina, Ushuaia, Argentina, Sailing In The Beagle Channel, Punta Arenas, Chile, Puerto Chacabuco, Chile, Puerto Montt, Chile and Iles des Saintes, Guadeloupe, starting at 8119.0 per person.

21 Night South America Cruise

22 Night Europe Cruise aboard the Azamara Quest departing from Buenos Aires, Argentina, on 2026-02-08, cruises to Montevideo, Uruguay, Punta del Este, Uruguay, South Orkney Islands, Antarctica, Ushuaia, Argentina, Ushuaia, Argentina, Ushuaia, Argentina, Sailing In The Beagle Channel, Punta Arenas, Chile, Puerto Chacabuco, Chile, Castro, Chile, Puerto Montt, Chile, Iles des Saintes, Guadeloupe and Iles des Saintes, Guadeloupe, starting at 6019.4 per person.

22 Night Europe Cruise

Holland America Line

29 Night World Cruise aboard the Zaandam departing from Buenos Aires, Argentina, on 2027-02-13, cruises to Santos (Sao Paulo), Brazil, Abraao, Ilha Grande, Brazil, Rio de Janeiro, Brazil, Rio de Janeiro, Brazil, Bahia de Salvador, Brazil, Recife, Brazil, Fortaleza, Brazil, Belem, Brazil, Devils Island, French Guiana, Bridgetown, Barbados, Castries, St. Lucia, Port of Basseterre, St. Kitts, St. Kitts and Nevis, San Juan, Puerto Rico and Fort Lauderdale (Port Everglades), Florida, starting at 5899.0 per person.

29 Night World Cruise

31 Night South America Cruise aboard the Oosterdam departing from Buenos Aires, Argentina, on 2027-03-09, cruises to Montevideo, Uruguay, Stanley, Falkland Islands, Ushuaia, Argentina, Punta Arenas, Chile, Pio Xi Glacier (bruggen Glacier), Chile, Puerto Montt, Chile, San Antonio, Santiago, Chile, Coquimbo (La Serena), Chile, General San Martin, Peru, Callao (Lima), Peru, Callao (Lima), Peru, Salaverry (Trujillo), Peru, Manta (Quito), Ecuador, Fuerte Amador, Panama, Fuerte Amador, Panama, Panama Canal, Panama, Georgetown, Grand Cayman, Cayman Islands and Fort Lauderdale (Port Everglades), Florida, starting at 3444.0 per person.

31 Night South America Cruise

Carnival Cruise Line

Journeys - 16 Day South America aboard the Carnival Firenze departing from Buenos Aires, Argentina, on 2027-02-02, cruises to Rio de Janeiro, Brazil, Maceio, Brazil (dock), Grenada, Caribbean, Fort-de-France, Martinique, Philipsburg, St. Maarten and Miami, Florida, starting at 1429.09 per person.

Journeys - 16 Day South America

Popular Sailings

Browse Cruise Lines

Azamara Journey

Oosterdam

Seven Seas Splendor

Insignia

Marina

Browse Cruise Ships

Buenos Aires, Argentina

Punta del Este, Uruguay

Rio Grande, Rio Grande do Sul, Brazil

Porto Belo (Santa Catarina), Brazil

Santos (Sao Paulo), Brazil

Ilha Grande, Brazil

Rio de Janeiro, Brazil

Buzios, Brazil

Bahia de Salvador, Brazil

Maceio, Brazil

Recife, Brazil

Belem, Brazil

Devils Island, French Guiana

Castries, St. Lucia

Roseau, Dominica

Philipsburg, St. Maarten

Miami, Florida

Montevideo, Uruguay

South Orkney Islands, Antarctica

Ushuaia, Argentina

Sailing In The Beagle Channel

Punta Arenas, Chile

Puerto Chacabuco, Chile

Puerto Montt, Chile

Iles des Saintes, Guadeloupe

Coquimbo (La Serena), Chile

Iquique, Chile

Arica, Chile

Pisco (Puerto San Martin), Peru

Callao (Lima), Peru

Panama City, Panama

Panama Canal, Panama

Puerto Limon, Costa Rica

San Andres Island, Colombia

Cozumel, Mexico

Itajai, Brazil

Paraty, Brazil

Alter do Chao, Brazil

Boca da Valeria, Brazil

Manaus, Brazil

Parintins, Brazil

Santarem, Brazil

Port of Basseterre, St. Kitts, St. Kitts and Nevis

Oceania Marina

Florianopolis, Brazil

Bridgetown, Barbados

St. John's, Antigua

Charlotte Amalie, St. Thomas, U.S. Virgin Islands

Oceania  Insignia

Castro, Chile

Azamara Quest

Abraao, Ilha Grande, Brazil

Fortaleza, Brazil

San Juan, Puerto Rico

Fort Lauderdale (Port Everglades), Florida

Zaandam

Stanley, Falkland Islands

Pio Xi Glacier (bruggen Glacier), Chile

San Antonio, Santiago, Chile

General San Martin, Peru

Salaverry (Trujillo), Peru

Manta (Quito), Ecuador

Fuerte Amador, Panama

Georgetown, Grand Cayman, Cayman Islands

Maceio, Brazil (dock)

Grenada, Caribbean

Fort-de-France, Martinique

Carnival Firenze

Caribbean