Find and compare cruises to South America in 2025 with Regent. Get cruise deals, including last-minute deals.

Book cruises to South America in 2025 with Regent Online and Save

Cruisebound

30 Night Caribbean - Eastern Cruise aboard the Seven Seas Splendor departing from Miami, Florida, on 2025-11-17, cruises to Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Belize, Roatan, Honduras, Puerto Limon, Costa Rica, Colon, Panama, Panama Canal, Panama, Cartagena, Colombia, Cartagena, Colombia, Oranjestad, Sint Eustatius, Willemstad, Curacao, Kralendijk, Bonaire, Dutch Antilles, St. George, Bermuda, Bridgetown, Barbados, Port of Kingstown, St. Vincent & the Grenadines, Scarborough, Tobago, Devils Island, French Guiana, Fortaleza, Brazil, Recife, Brazil, Maceio, Brazil, Bahia de Salvador, Brazil, Rio de Janeiro, Brazil and Rio de Janeiro, Brazil, starting at 18299.00 per person.

30 Night Caribbean - Eastern Cruise

16 Night Europe - Western Cruise aboard the Seven Seas Grandeur departing from Le Havre (Paris), France, on 2025-09-09, cruises to Bordeaux, France, Bordeaux, France, Bordeaux, France, Bilbao, Spain, Gijon, Spain, La Coruna, Spain, Porto (Oporto), Portugal, Lisbon, Portugal, Cadiz (Seville), Spain, Malaga, Spain, Cartagena, Colombia, Valencia, Spain, Palma de Mallorca, Spain and Barcelona, Spain, starting at 15599.0 per person.

16 Night Europe - Western Cruise

17 Night South America Cruise aboard the Seven Seas Splendor departing from Buenos Aires, Argentina, on 2025-12-28, cruises to Puerto Madryn, Argentina, Punta Arenas, Chile, Punta Arenas, Chile, Ushuaia, Argentina, South Orkney Islands, Antarctica and Montevideo, Uruguay, starting at 11240.0 per person.

17 Night South America Cruise

16 Night Transatlantic Cruise aboard the Seven Seas Grandeur departing from Barcelona, Spain, on 2025-11-08, cruises to Cartagena, Colombia, Malaga, Spain, Cadiz (Seville), Spain, Funchal, Madeira, Portugal, Royal Naval Dockyard, Bermuda, Royal Naval Dockyard, Bermuda, Nassau, Bahamas and Miami, Florida, starting at 9599.0 per person.

16 Night Transatlantic Cruise

16 Night Caribbean - Eastern Cruise aboard the Seven Seas Splendor departing from Miami, Florida, on 2025-11-17, cruises to Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Belize, Roatan, Honduras, Puerto Limon, Costa Rica, Colon, Panama, Panama Canal, Panama, Cartagena, Colombia, Cartagena, Colombia, Oranjestad, Sint Eustatius, Willemstad, Curacao, Kralendijk, Bonaire, Dutch Antilles, St. George, Bermuda and Bridgetown, Barbados, starting at 9299.00 per person.

16 Night Caribbean - Eastern Cruise

14 Night South America Cruise aboard the Seven Seas Splendor departing from Bridgetown, Barbados, on 2025-12-03, cruises to Port of Kingstown, St. Vincent & the Grenadines, Scarborough, Tobago, Devils Island, French Guiana, Fortaleza, Brazil, Recife, Brazil, Maceio, Brazil, Bahia de Salvador, Brazil, Rio de Janeiro, Brazil and Rio de Janeiro, Brazil, starting at 8660.0 per person.

14 Night South America Cruise

10 Night Mediterranean - Western Cruise aboard the Seven Seas Voyager departing from Lisbon, Portugal, on 2025-09-14, cruises to Cadiz (Seville), Spain, Malaga, Spain, Cartagena, Colombia, Alicante, Spain, Mahon, Minorca, Spain, Palamos, Spain, Sete, France and Barcelona, Spain, starting at 7699.0 per person.

10 Night Mediterranean - Western Cruise

11 Night South America Cruise aboard the Seven Seas Splendor departing from Rio de Janeiro, Brazil, on 2025-12-17, cruises to Ilha Grande, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil, Porto Belo (Santa Catarina), Brazil, Rio Grande, Rio Grande do Sul, Brazil, Punta del Este, Uruguay, Montevideo, Uruguay, Buenos Aires, Argentina and Buenos Aires, Argentina, starting at 7599.0 per person.

11 Night South America Cruise

Popular Sailings

Barcelona

Miami, Florida

Rio de Janeiro

Bridgetown, Barbados

Lisbon, Portugal

Explore Departure Ports

Seven Seas Splendor

Seven Seas Grandeur

Seven Seas Voyager

Browse Cruise Ships

Cozumel, Mexico

Costa Maya, Mexico

Harvest Caye, Belize

Roatan, Honduras

Puerto Limon, Costa Rica

Colon, Panama

Panama Canal, Panama

Cartagena, Colombia

Oranjestad, Sint Eustatius

Willemstad, Curacao

Kralendijk, Bonaire, Dutch Antilles

St. George, Bermuda

Port of Kingstown, St. Vincent & the Grenadines

Scarborough, Tobago

Devils Island, French Guiana

Fortaleza, Brazil

Recife, Brazil

Maceio, Brazil

Bahia de Salvador, Brazil

Rio de Janeiro, Brazil

Regent Seven Seas Cruises

Le Havre (Paris), France

Bordeaux, France

Bilbao, Spain

Gijon, Spain

La Coruna, Spain

Porto (Oporto), Portugal

Cadiz (Seville), Spain

Malaga, Spain

Valencia, Spain

Palma de Mallorca, Spain

Barcelona, Spain

Buenos Aires, Argentina

Puerto Madryn, Argentina

Punta Arenas, Chile

Ushuaia, Argentina

South Orkney Islands, Antarctica

Montevideo, Uruguay

Funchal, Madeira, Portugal

Royal Naval Dockyard, Bermuda

Nassau, Bahamas

Alicante, Spain

Mahon, Minorca, Spain

Palamos, Spain

Sete, France

Ilha Grande, Brazil

Ilhabela, Brazil

Santos (Sao Paulo), Brazil

Porto Belo (Santa Catarina), Brazil

Rio Grande, Rio Grande do Sul, Brazil

Punta del Este, Uruguay

South America