Find and compare cruises to South America in 2025 with Oceania. Get cruise deals, including last-minute deals.

Book cruises to South America in 2025 with Oceania Online and Save

Cruisebound

42 Night World Cruise aboard the Marina departing from Miami, Florida, on 2025-11-29, cruises to Cozumel, Mexico, Costa Maya, Mexico, Belize City, Belize, Harvest Caye, Belize, Santo Tomas de Castilla, Guatemala, Roatan, Honduras, Puerto Limon, Costa Rica, Panama City, Panama, Panama City, Panama, Manta (Quito), Ecuador, Guayaquil (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Coquimbo (La Serena), Chile, San Antonio, Santiago, Chile, San Antonio, Santiago, Chile, Puerto Montt, Chile, Castro, Chile, Puerto Chacabuco, Chile, Laguna San Raphael, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Port Stanley, Falkland Islands, Puerto Madryn, Argentina and Buenos Aires, Argentina, starting at 11199.0 per person.

42 Night World Cruise

10 Night Mediterranean Cruise aboard the Vista departing from Bilbao, Spain, on 2025-09-04, cruises to Gijon, Spain, La Coruna, Spain, Leixoes (Oporto), Portugal, Lisbon, Portugal, Lisbon, Portugal, Tangier, Morocco, Almeria, Spain, Cartagena, Colombia, Palma de Mallorca, Spain and Barcelona, Spain, starting at 12999.0 per person.

10 Night Mediterranean Cruise

37 Night World Cruise aboard the Insignia departing from Papeete, Tahiti, French Polynesia, on 2025-06-16, cruises to Moorea, French Polynesia, Fakarava, Tahiti, Nuku Hiva Marquesas, Honolulu, Oahu, Hawaii, Honolulu, Oahu, Hawaii, Hilo, Hawaii, San Diego, California, Cabo San Lucas, Mexico, Zihuatanejo (Ixtapa/Zihuatanejo), Mexico, Puerto Quetzal, Guatemala, Puerto Corinto, Nicaragua, Puntarenas, Costa Rica, Cartagena, Colombia, Georgetown, Grand Cayman, Cayman Islands, Miami, Florida, Port Canaveral, Florida, New York, New York and New York, New York, starting at 10399.0 per person.

37 Night World Cruise

26 Night World Cruise aboard the Nautica departing from Piraeus (Athens), Greece, on 2025-09-11, cruises to Mykonos, Greece, Mytilene, Lesbos, Greece, Bozcaada, Turkey, Istanbul, Turkey, Istanbul, Turkey, Ephesus, Turkey, Marmaris, Turkey, Antalya, Turkey, Limassol, Cyprus, Rhodes, Greece, Santorini (Thira), Greece, Heraklion, Crete, Greece, Valletta, Malta, La Goulette, Tunisia, Palermo, Sicily, Italy, Naples, Italy, Civitavecchia (Rome), Italy, Florence, Italy, Calvi, France, Cannes, France, Toulon, France, Barcelona, Spain, Palma de Mallorca, Spain, Cartagena, Colombia and Malaga, Spain, starting at 7599.0 per person.

26 Night World Cruise

10 Night Mediterranean Cruise aboard the Allura departing from Monte Carlo, Monaco, on 2025-09-06, cruises to Marseille, France, Barcelona, Spain, Palma de Mallorca, Spain, Cartagena, Colombia, Malaga, Spain, Gibraltar, British Territory, Tangier, Morocco, Seville, Spain, Portimao, Portugal and Lisbon, Portugal, starting at 7049.0 per person.

25 Night South America Cruise aboard the Insignia departing from Miami, Florida, on 2025-11-12, cruises to St. John's, Antigua, Castries, St. Lucia, St. Georges, Grenada, West Indies, Scarborough, Tobago, Santarem, Brazil, Boca da Valeria, Brazil, Manaus, Brazil, Manaus, Brazil, Parintins, Brazil, Alter do Chao, Brazil, Bridgetown, Barbados, Roseau, Dominica, Philipsburg, St. Maarten and San Juan, Puerto Rico, starting at 6999.0 per person.

25 Night South America Cruise

17 Night Panama Canal Cruise aboard the Vista departing from Los Angeles, California, on 2025-12-20, cruises to Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Corinto, Nicaragua, Puntarenas, Costa Rica, Cartagena, Colombia, Georgetown, Grand Cayman, Cayman Islands and Miami, Florida, starting at 6399.0 per person.

17 Night Panama Canal Cruise

20 Night Panama Canal Cruise aboard the Insignia departing from San Diego, California, on 2025-07-03, cruises to Cabo San Lucas, Mexico, Zihuatanejo (Ixtapa/Zihuatanejo), Mexico, Puerto Quetzal, Guatemala, Puerto Corinto, Nicaragua, Puntarenas, Costa Rica, Cartagena, Colombia, Georgetown, Grand Cayman, Cayman Islands, Miami, Florida, Port Canaveral, Florida, New York, New York and New York, New York, starting at 6199.0 per person.

20 Night Panama Canal Cruise

20 Night South America Cruise aboard the Marina departing from San Antonio, Santiago, Chile, on 2025-12-21, cruises to Puerto Montt, Chile, Castro, Chile, Puerto Chacabuco, Chile, Laguna San Raphael, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Port Stanley, Falkland Islands, Puerto Madryn, Argentina and Buenos Aires, Argentina, starting at 5799.0 per person.

20 Night South America Cruise

22 Night South America Cruise aboard the Marina departing from Miami, Florida, on 2025-11-29, cruises to Cozumel, Mexico, Costa Maya, Mexico, Belize City, Belize, Harvest Caye, Belize, Santo Tomas de Castilla, Guatemala, Roatan, Honduras, Puerto Limon, Costa Rica, Panama City, Panama, Panama City, Panama, Manta (Quito), Ecuador, Guayaquil (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Coquimbo (La Serena), Chile, San Antonio, Santiago, Chile and San Antonio, Santiago, Chile, starting at 5699.0 per person.

22 Night South America Cruise

Popular Sailings

Miami, Florida

Monaco

Rome (Civitavecchia)

Malta (La Valletta)

Los Angeles

Explore Departure Ports

Marina

Insignia

Vista

Allura

Nautica

Browse Cruise Ships

Cozumel, Mexico

Costa Maya, Mexico

Belize City, Belize

Harvest Caye, Belize

Santo Tomas de Castilla, Guatemala

Roatan, Honduras

Puerto Limon, Costa Rica

Panama City, Panama

Manta (Quito), Ecuador

Guayaquil (Quito), Ecuador

Salaverry (Trujillo), Peru

Callao (Lima), Peru

Coquimbo (La Serena), Chile

San Antonio, Santiago, Chile

Puerto Montt, Chile

Castro, Chile

Puerto Chacabuco, Chile

Laguna San Raphael, Chile

Punta Arenas, Chile

Ushuaia, Argentina

Port Stanley, Falkland Islands

Puerto Madryn, Argentina

Buenos Aires, Argentina

Oceania Cruises

Bilbao, Spain

Gijon, Spain

La Coruna, Spain

Leixoes (Oporto), Portugal

Lisbon, Portugal

Tangier, Morocco

Almeria, Spain

Cartagena, Colombia

Palma de Mallorca, Spain

Barcelona, Spain

Papeete, Tahiti, French Polynesia

Moorea, French Polynesia

Fakarava, Tahiti

Nuku Hiva Marquesas

Honolulu, Oahu, Hawaii

Hilo, Hawaii

San Diego, California

Cabo San Lucas, Mexico

Zihuatanejo (Ixtapa/Zihuatanejo), Mexico

Puerto Quetzal, Guatemala

Puerto Corinto, Nicaragua

Puntarenas, Costa Rica

Georgetown, Grand Cayman, Cayman Islands

Port Canaveral, Florida

New York, New York

Piraeus (Athens), Greece

Mykonos, Greece

Mytilene, Lesbos, Greece

Bozcaada, Turkey

Istanbul, Turkey

Ephesus, Turkey

Marmaris, Turkey

Antalya, Turkey

Limassol, Cyprus

Rhodes, Greece

Santorini (Thira), Greece

Heraklion, Crete, Greece

Valletta, Malta

La Goulette, Tunisia

Palermo, Sicily, Italy

Naples, Italy

Civitavecchia (Rome), Italy

Florence, Italy

Calvi, France

Cannes, France

Toulon, France

Malaga, Spain

Monte Carlo, Monaco

Marseille, France

Gibraltar, British Territory

Seville, Spain

Portimao, Portugal

St. John's, Antigua

Castries, St. Lucia

St. Georges, Grenada, West Indies

Scarborough, Tobago

Santarem, Brazil

Boca da Valeria, Brazil

Manaus, Brazil

Parintins, Brazil

Alter do Chao, Brazil

Bridgetown, Barbados

Roseau, Dominica

Philipsburg, St. Maarten

San Juan, Puerto Rico

Los Angeles, California

Puerto Vallarta, Mexico

Manzanillo, Mexico

Acapulco, Mexico

South America