Find and book South America cruises from Fort Lauderdale (Port Everglades), Florida online. Search the best cruise deals, including last-minute deals.

Book Cruises To South America From Fort Lauderdale Port Everglades Florida Online And Save

Cruisebound

Holland America Line

16 Night South America Cruise aboard the Oosterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-11-18, cruises to Georgetown, Grand Cayman, Cayman Islands, Panama Canal, Panama, Fuerte Amador, Panama, Fuerte Amador, Panama, Manta (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Callao (Lima), Peru, General San Martin, Peru, Coquimbo (La Serena), Chile and San Antonio, Santiago, Chile, starting at 1169.0 per person.

16 Night South America Cruise

Princess Cruises

14 Night Caribbean - Southern Cruise aboard the Coral Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-08, cruises to St. Maarten, Netherlands Antilles, Port of Basseterre, St. Kitts, St. Kitts and Nevis, Fort-de-France, Martinique, Dominica, Caribbean, St. Georges, Grenada, West Indies, Trinidad, Trinidad and Tobago, Curacao, Caribbean and Port of Oranjestad, Aruba, Caribbean, starting at 1049.0 per person.

14 Night Caribbean - Southern Cruise

15 Night Panama Canal Cruise aboard the Eurodam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-04-05, cruises to Cartagena, Colombia, Panama Canal, Panama, Puntarenas, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico and San Diego, California, starting at 1014.0 per person.

15 Night Panama Canal Cruise

Celebrity Cruises

11 Nt Panama Canal & Southern Caribbean aboard the Celebrity Ascent departing from Fort Lauderdale (Port Everglades), Florida, on 2026-11-23, cruises to Cartagena, Colombia, Colon, Panama, Panama Canal, Panama, Port of Oranjestad, Aruba, Caribbean, Willemstad, Curacao and Kralendijk, Bonaire, Dutch Antilles, starting at 999.0 per person.

11 Nt Panama Canal & Southern Caribbean

21 Night Panama Canal Cruise aboard the Rotterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-28, cruises to Willemstad, Curacao, Port of Oranjestad, Aruba, Caribbean, Port of Oranjestad, Aruba, Caribbean, Half Moon Cay (Little San Salvador Island), Bahamas, Half Moon Cay (Little San Salvador Island), Bahamas, Willemstad, Curacao, Cartagena, Colombia, Gatun Lake, Panama Canal, Panama, Colon, Panama, Panama Canal, Panama, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 869.0 per person.

21 Night Panama Canal Cruise

12 Night Caribbean - Southern Cruise aboard the Caribbean Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2026-03-17, cruises to Port of Oranjestad, Aruba, Caribbean, Curacao, Caribbean, Cartagena, Colombia, Colon, Panama, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 779.0 per person.

12 Night Caribbean - Southern Cruise

17 Night South America Cruise aboard the Oosterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-17, cruises to Georgetown, Grand Cayman, Cayman Islands, Fuerte Amador, Panama, Panama Canal, Panama, Fuerte Amador, Panama, Manta (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Callao (Lima), Peru, Callao (Lima), Peru, General San Martin, Peru, Coquimbo (La Serena), Chile and San Antonio, Santiago, Chile, starting at 724.0 per person.

17 Night South America Cruise

16 Night Transcanal Cruise aboard the Island Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-21, cruises to Cartagena, Colombia, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama, Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Manzanillo, Mexico and San Francisco, California, starting at 709.0 per person.

16 Night Transcanal Cruise

12 Night Transcanal Cruise aboard the Caribbean Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-17, cruises to Port of Oranjestad, Aruba, Caribbean, Curacao, Caribbean, Cartagena, Colombia, Panama Canal,partial Transit, Colon, Panama, Puerto Limon, Costa Rica and Ocho Rios, Jamaica, starting at 419.0 per person.

12 Night Transcanal Cruise

12 Night Panama Canal Cruise aboard the Rotterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-07, cruises to Half Moon Cay (Little San Salvador Island), Bahamas, Willemstad, Curacao, Cartagena, Colombia, Colon, Panama, Gatun Lake, Panama Canal, Panama, Panama Canal, Panama, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 409.0 per person.

12 Night Panama Canal Cruise

Popular Sailings

Cunard

Viking Ocean Cruises

Browse Cruise Lines

Nieuw Amsterdam

Caribbean Princess

Rotterdam

Eurodam

Coral Princess

Browse Cruise Ships

Fort Lauderdale (Port Everglades), Florida

Georgetown, Grand Cayman, Cayman Islands

Panama Canal, Panama

Fuerte Amador, Panama

Manta (Quito), Ecuador

Salaverry (Trujillo), Peru

Callao (Lima), Peru

General San Martin, Peru

Coquimbo (La Serena), Chile

San Antonio, Santiago, Chile

Oosterdam

St. Maarten, Netherlands Antilles

Port of Basseterre, St. Kitts, St. Kitts and Nevis

Fort-de-France, Martinique

Dominica, Caribbean

St. Georges, Grenada, West Indies

Trinidad, Trinidad and Tobago

Curacao, Caribbean

Port of Oranjestad, Aruba, Caribbean

Cartagena, Colombia

Enter Panama Canal Cristobal (cruising Only Transit Times Are Approximate)

Puntarenas (puerto Caldera), Costa Passport Required

Puntarenas, Costa Rica

Acajutla, El Salvador

Puerto Quetzal, Guatemala

Puerto Vallarta, Mexico

Cabo San Lucas, Mexico Tender Required Wheelchair Access Limited

Cabo San Lucas, Mexico

San Diego, California

Colon, Panama

Willemstad, Curacao

Kralendijk, Bonaire, Dutch Antilles

Celebrity Ascent

Half Moon Cay, Bahamas (tender Required Wheelchair Access Limited)

Half Moon Cay (Little San Salvador Island), Bahamas

Gatun Lake, Panama (cruising Only Shore Excursion Guests Only)

Gatun Lake, Panama Canal, Panama

Cruising Panama Canal And Gatun Lak (cruising Only)

Puerto Limon (san Jose), Costa Rica (passport Required)

Puerto Limon, Costa Rica

Georgetown, Cayman Islands (tender Required Wheelchair Access Limited)

Georgetown, Cayman Islands Tender Required Wheelchair Access Limited

Fuerte Amador, Panama Overnight Times Subject To Canal Transit

Fuerte Amador, Panama Times Subject To Canal Transit

Coquimbo (la Serena), Chile Visa Req For Some

San Antonio (santiago), Chile Visa Req For Some