Find and compare cruises to the Panama Canal in 2026 with Princess. Get cruise deals, including last-minute deals.

Book cruises to the Panama Canal in 2026 with Princess Online and Save

Cruisebound

36 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru, Coquimbo (La Serena), Chile, San Antonio, Chile, Puerto Montt, Chile, Chacabuco, Chile, Amalia (Skua) Glacier, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Cape Horn (scenic Cruising), Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina and Buenos Aires, Argentina, starting at 3898.0 per person.

36 Night South America Cruise

20 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru and Coquimbo (La Serena), Chile, starting at 1998.0 per person.

20 Night South America Cruise

20 Night Transcanal Cruise aboard the Star Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2026-04-13, cruises to Port of Oranjestad, Aruba, Caribbean, Panama Canal Full Transit New Locks, Fuerte Amador, Panama, Mazatlan, Mexico, Cabo San Lucas, Mexico, Los Angeles, California and Seattle, Washington, starting at 1648.0 per person.

20 Night Transcanal Cruise

22 Night Transcanal Cruise aboard the Coral Princess departing from Vancouver, British Columbia, on 2026-09-23, cruises to San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit Historic Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 1487.0 per person.

22 Night Transcanal Cruise

27 Night Caribbean - Southern Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean, Fort Lauderdale (Port Everglades), Florida, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Kralendijk, Bonaire, Dutch Antilles, Curacao, Caribbean, Port of Oranjestad, Aruba, Caribbean, Port of Basseterre, St. Kitts, St. Kitts and Nevis, St. Thomas, U.S. Virgin Islands and San Juan, Puerto Rico, starting at 1358.0 per person.

27 Night Caribbean - Southern Cruise

23 Night Transcanal Cruise aboard the Caribbean Princess departing from Vancouver, British Columbia, on 2025-09-23, cruises to San Francisco, California, Avalon, Catalina Island, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 1328.0 per person.

23 Night Transcanal Cruise

18 Night Transcanal Cruise aboard the Island Princess departing from New York, New York, on 2025-09-18, cruises to Grand Turk, Turks and Caicos, Port of Oranjestad, Aruba, Caribbean, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama, Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico and Los Angeles, California, starting at 1278.0 per person.

18 Night Transcanal Cruise

17 Night Transcanal Cruise aboard the Ruby Princess departing from San Francisco, California, on 2026-08-31, cruises to Mazatlan, Mexico, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Cartagena, Colombia and Fort Lauderdale (Port Everglades), Florida, starting at 778.0 per person.

17 Night Transcanal Cruise

16 Night Transcanal Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 549.0 per person.

16 Night Transcanal Cruise

12 Night Transcanal Cruise aboard the Caribbean Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-11, cruises to Port of Oranjestad, Aruba, Caribbean, Kralendijk, Bonaire, Dutch Antilles, Cartagena, Colombia, Colon, Panama, Panama Canal,partial Transit, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 499.0 per person.

12 Night Transcanal Cruise

Popular Sailings

 Fort Lauderdale (Port Everglades)

Los Angeles

Vancouver

San Francisco, California

San Juan, Puerto Rico

Explore Departure Ports

Caribbean Princess

Island Princess

Coral Princess

Star Princess

Grand Princess

Browse Cruise Ships

Los Angeles, California

Manzanillo, Mexico

Puntarenas, Costa Rica

Fuerte Amador, Panama

Manta (Quito), Ecuador

Callao (Lima), Peru

Pisco (Puerto San Martin), Peru

Coquimbo (La Serena), Chile

San Antonio, Chile

Puerto Montt, Chile

Chacabuco, Chile

Amalia (Skua) Glacier, Chile

Punta Arenas, Chile

Ushuaia, Argentina

Cape Horn (scenic Cruising)

Stanley, Falkland Islands

Puerto Madryn, Argentina

Montevideo, Uruguay

Buenos Aires, Argentina

Princess Cruises

Sapphire Princess

Fort Lauderdale (Port Everglades), Florida

Port of Oranjestad, Aruba, Caribbean

Panama Canal Full Transit New Locks

Mazatlan, Mexico

Cabo San Lucas, Mexico

Seattle, Washington

Vancouver, British Columbia

San Diego, California

Puerto Vallarta, Mexico

Huatulco, Mexico

Puerto Chiapas, Mexico

Panama Canal Full Transit Historic Locks

Grand Turk, Turks and Caicos

Amber Cove, Dominican Republic

Kralendijk, Bonaire, Dutch Antilles

Curacao, Caribbean

Port of Basseterre, St. Kitts, St. Kitts and Nevis

St. Thomas, U.S. Virgin Islands

Avalon, Catalina Island, California

New York, New York

Puerto Quetzal, Guatemala

Cartagena, Colombia

Ruby Princess

Colon, Panama

Panama Canal,partial Transit

Puerto Limon, Costa Rica

Georgetown, Grand Cayman, Cayman Islands

Panama Canal