Find and compare cruises to the Panama Canal in 2025 with Princess. Get cruise deals, including last-minute deals.

Book cruises to the Panama Canal in 2025 with Princess Online and Save

Cruisebound

53 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru, Coquimbo (La Serena), Chile, San Antonio, Chile, Puerto Montt, Chile, Chacabuco, Chile, Amalia (Skua) Glacier, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Cape Horn (scenic Cruising), Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina, Buenos Aires, Argentina, Buenos Aires, Argentina, Punta Arenas, Chile, Ushuaia, Argentina, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Stanley, Falkland Islands, Montevideo, Uruguay and Buenos Aires, Argentina, starting at 7848.0 per person.

53 Night South America Cruise

36 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru, Coquimbo (La Serena), Chile, San Antonio, Chile, Puerto Montt, Chile, Chacabuco, Chile, Amalia (Skua) Glacier, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Cape Horn (scenic Cruising), Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina and Buenos Aires, Argentina, starting at 4558.0 per person.

36 Night South America Cruise

20 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru and Coquimbo (La Serena), Chile, starting at 2346.0 per person.

20 Night South America Cruise

27 Night Caribbean - Southern Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean, Fort Lauderdale (Port Everglades), Florida, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Kralendijk, Bonaire, Dutch Antilles, Curacao, Caribbean, Port of Oranjestad, Aruba, Caribbean, Port of Basseterre, St. Kitts, St. Kitts and Nevis, St. Thomas, U.S. Virgin Islands and San Juan, Puerto Rico, starting at 1358.0 per person.

27 Night Caribbean - Southern Cruise

23 Night Transcanal Cruise aboard the Caribbean Princess departing from Vancouver, British Columbia, on 2025-09-23, cruises to San Francisco, California, Avalon, Catalina Island, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 1328.0 per person.

23 Night Transcanal Cruise

18 Night Transcanal Cruise aboard the Island Princess departing from New York, New York, on 2025-09-18, cruises to Grand Turk, Turks and Caicos, Port of Oranjestad, Aruba, Caribbean, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama, Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico and Los Angeles, California, starting at 1178.0 per person.

18 Night Transcanal Cruise

16 Night Transcanal Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 549 per person.

16 Night Transcanal Cruise

12 Night Transcanal Cruise aboard the Caribbean Princess departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-11, cruises to Port of Oranjestad, Aruba, Caribbean, Kralendijk, Bonaire, Dutch Antilles, Cartagena, Colombia, Colon, Panama, Panama Canal,partial Transit, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 499 per person.

12 Night Transcanal Cruise

Popular Sailings

 Fort Lauderdale (Port Everglades)

Los Angeles

Port Canaveral

Vancouver

New York

Explore Departure Ports

Caribbean Princess

Island Princess

Coral Princess

Sapphire Princess

Grand Princess

Browse Cruise Ships

Los Angeles, California

Manzanillo, Mexico

Puntarenas, Costa Rica

Fuerte Amador, Panama

Manta (Quito), Ecuador

Callao (Lima), Peru

Pisco (Puerto San Martin), Peru

Coquimbo (La Serena), Chile

San Antonio, Chile

Puerto Montt, Chile

Chacabuco, Chile

Amalia (Skua) Glacier, Chile

Punta Arenas, Chile

Ushuaia, Argentina

Cape Horn (scenic Cruising)

Stanley, Falkland Islands

Puerto Madryn, Argentina

Montevideo, Uruguay

Buenos Aires, Argentina

Antarctic Peninsula, Antarctica

Princess Cruises

Huatulco, Mexico

Puerto Chiapas, Mexico

Panama Canal Full Transit New Locks

Port of Oranjestad, Aruba, Caribbean

Fort Lauderdale (Port Everglades), Florida

Grand Turk, Turks and Caicos

Amber Cove, Dominican Republic

Kralendijk, Bonaire, Dutch Antilles

Curacao, Caribbean

Port of Basseterre, St. Kitts, St. Kitts and Nevis

St. Thomas, U.S. Virgin Islands

San Juan, Puerto Rico

Vancouver, British Columbia

San Francisco, California

Avalon, Catalina Island, California

San Diego, California

Puerto Vallarta, Mexico

New York, New York

Panama Canal Full Transit Historic Locks

Cartagena, Colombia

Colon, Panama

Panama Canal,partial Transit

Puerto Limon, Costa Rica

Georgetown, Grand Cayman, Cayman Islands

Panama Canal