Find and compare cruises to the Mediterranean in 2025 with MSC Cruises. Get cruise deals, including last-minute deals.

Book cruises to the Mediterranean in 2025 with MSC Cruises Online and Save

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5 Night Mediterranean - Western Cruise aboard the MSC Orchestra departing from Marseille, France, on 2025-11-12, cruises to Livorno (Florence/Pisa), Italy, Valencia, Spain and Barcelona, Spain, starting at 438.0 per person.

5 Night Mediterranean - Western Cruise

7 Night Europe - Northern Cruise aboard the MSC Virtuosa departing from Southampton, England, on 2025-05-31, cruises to La Rochelle, France, Bilbao, Spain, La Coruna, Spain and Cherbourg, France, starting at 741.0 per person.

7 Night Europe - Northern Cruise

5 Night Mediterranean - Western Cruise aboard the MSC Grandiosa departing from Palermo, Sicily, Italy, on 2025-11-10, cruises to Ibiza, Spain, Valencia, Spain, Marseille, France and Genoa, Italy, starting at 539.0 per person.

10 Night Mediterranean Cruise aboard the MSC Fantasia departing from Trieste, Italy, on 2025-10-29, cruises to Zadar, Croatia, Dubrovnik, Croatia, Bari, Italy, Corfu, Greece, Valletta, Malta, Messina, Sicily, Italy, Civitavecchia (Rome), Italy and Barcelona, Spain, starting at 1503.0 per person.

10 Night Mediterranean Cruise

5 Night Mediterranean Cruise aboard the MSC Magnifica departing from Marseille, France, on 2025-12-16, cruises to Barcelona, Spain, Civitavecchia (Rome), Italy and Genoa, Italy, starting at 359.0 per person.

5 Night Mediterranean Cruise

7 Night Mediterranean - Western Cruise aboard the MSC Orchestra departing from Genoa, Italy, on 2025-12-16, cruises to Livorno (Florence/Pisa), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain and Marseille, France, starting at 422.0 per person.

7 Night Mediterranean - Western Cruise

7 Night Mediterranean Cruise aboard the MSC Fantasia departing from Bari, Italy, on 2025-11-01, cruises to Corfu, Greece, Valletta, Malta, Messina, Sicily, Italy, Civitavecchia (Rome), Italy and Barcelona, Spain, starting at 559.0 per person.

7 Night Mediterranean Cruise

10 Night Mediterranean - Western Cruise aboard the MSC Musica departing from Marseille, France, on 2025-10-14, cruises to Malaga, Spain, Cadiz (Seville), Spain, Lisbon, Portugal, Alicante, Spain, Mahon, Minorca, Spain, Olbia, Italy and Genoa, Italy, starting at 1173.0 per person.

10 Night Mediterranean - Western Cruise

5 Night Mediterranean Cruise aboard the MSC Magnifica departing from Genoa, Italy, on 2025-12-15, cruises to Marseille, France, Barcelona, Spain and Civitavecchia (Rome), Italy, starting at 359.0 per person.

5 Night Grand Voyage Cruise aboard the MSC Lirica departing from Venice, Italy, on 2025-11-07, cruises to Corfu, Greece, Syracuse, Sicily and Palermo, Sicily, Italy, starting at 329.0 per person.

5 Night Grand Voyage Cruise

Popular Sailings

Marseille

Genoa, Italy

Barcelona

Rome (Civitavecchia)

Naples

Explore Departure Ports

MSC World Europa

MSC Orchestra

MSC Splendida

MSC Grandiosa

MSC Magnifica

Browse Cruise Ships

Marseille, France

Livorno (Florence/Pisa), Italy

Valencia, Spain

Barcelona, Spain

MSC Cruises

Southampton, England

La Rochelle, France

Bilbao, Spain

La Coruna, Spain

Cherbourg, France

MSC Virtuosa

Palermo, Sicily, Italy

Ibiza, Spain

Trieste, Italy

Zadar, Croatia

Dubrovnik, Croatia

Bari, Italy

Corfu, Greece

Valletta, Malta

Messina, Sicily, Italy

Civitavecchia (Rome), Italy

MSC Fantasia

Malaga, Spain

Cadiz (Seville), Spain

Lisbon, Portugal

Alicante, Spain

Mahon, Minorca, Spain

Olbia, Italy

MSC Musica

Venice, Italy

Syracuse, Sicily

MSC Lirica

Mediterranean