Find and compare cruises to Central America in 2026 with Regent. Get cruise deals, including last-minute deals.

Book cruises to Central America in 2026 with Regent Online and Save

Cruisebound

21 Night Caribbean - Western Cruise aboard the Seven Seas Mariner departing from Miami, Florida, on 2025-12-20, cruises to Oranjestad, Sint Eustatius, Kralendijk, Bonaire, Dutch Antilles, Willemstad, Curacao, St. George, Bermuda, Castries, St. Lucia, Pointe-a-Pitre, Guadeloupe, Port of Basseterre, St. Kitts, St. Kitts and Nevis, Tortola, B.V.I., Cozumel, Mexico, Roatan, Honduras, Harvest Caye, Belize and Costa Maya, Mexico, starting at 12499.00 per person.

21 Night Caribbean - Western Cruise

7 Night Caribbean - Western Cruise aboard the Seven Seas Mariner departing from Miami, Florida, on 2026-01-03, cruises to Cozumel, Mexico, Roatan, Honduras, Harvest Caye, Belize and Costa Maya, Mexico, starting at 4399.00 per person.

7 Night Caribbean - Western Cruise

10 Night Caribbean - Western Cruise aboard the Seven Seas Mariner departing from Miami, Florida, on 2025-12-10, cruises to Georgetown, Grand Cayman, Cayman Islands, Falmouth, Cornwall, England, Belize City, Belize, Costa Maya, Mexico, Roatan, Honduras and Cozumel, Mexico, starting at 5799.0 per person.

10 Night Caribbean - Western Cruise

21 Night Transatlantic Cruise aboard the Seven Seas Grandeur departing from Civitavecchia (Rome), Italy, on 2026-11-08, cruises to Palma de Mallorca, Spain, Funchal, Madeira, Portugal, Royal Naval Dockyard, Bermuda, Miami, Florida, Roatan, Honduras, Harvest Caye, Belize, Belize City, Belize, Costa Maya, Mexico and Miami, Florida, starting at 11199.00 per person.

21 Night Transatlantic Cruise

17 Night Caribbean - Western Cruise aboard the Seven Seas Grandeur departing from Miami, Florida, on 2025-11-24, cruises to Costa Maya, Mexico, Harvest Caye, Belize, Roatan, Honduras, Cozumel, Mexico, San Juan, Puerto Rico, Gustavia, St. Barts, Philipsburg, St. Maarten, Frederikstad, St. Croix, Port Canaveral, Florida and Nassau, Bahamas, starting at 10999.00 per person.

17 Night Caribbean - Western Cruise

16 Night Panama Canal Cruise aboard the Seven Seas Grandeur departing from Miami, Florida, on 2026-12-29, cruises to Georgetown, Grand Cayman, Cayman Islands, Cartagena, Colombia, Panama Canal, Panama, Puntarenas, Costa Rica, Puerto Corinto, Nicaragua, Puerto Quetzal, Guatemala, Acapulco, Mexico, Cabo San Lucas, Mexico, San Diego, California and Los Angeles, California, starting at 10699.0 per person.

16 Night Panama Canal Cruise

16 Night Caribbean - Eastern Cruise aboard the Seven Seas Splendor departing from Miami, Florida, on 2025-11-17, cruises to Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Belize, Roatan, Honduras, Puerto Limon, Costa Rica, Colon, Panama, Panama Canal, Panama, Cartagena, Colombia, Cartagena, Colombia, Oranjestad, Sint Eustatius, Willemstad, Curacao, Kralendijk, Bonaire, Dutch Antilles, St. George, Bermuda and Bridgetown, Barbados, starting at 9199.00 per person.

16 Night Caribbean - Eastern Cruise

14 Night Caribbean - Eastern Cruise aboard the Seven Seas Splendor departing from Galveston, Texas, on 2026-12-28, cruises to Cozumel, Mexico, Belize City, Belize, Santo Tomas de Castilla, Guatemala, Roatan, Honduras, Montego Bay, Jamaica, Willemstad, Curacao, Oranjestad, Sint Eustatius, Kralendijk, Bonaire, Dutch Antilles and Miami, Florida, starting at 7899.00 per person.

14 Night Caribbean - Eastern Cruise

10 Night Mexico Cruise aboard the Seven Seas Grandeur departing from Panama City, Panama, on 2026-01-15, cruises to Puntarenas, Costa Rica, Puerto Corinto, Nicaragua, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Ensenada, Mexico and Los Angeles, California, starting at 7449.00 per person.

10 Night Mexico Cruise

12 Night Caribbean - Western Cruise aboard the Seven Seas Splendor departing from Galveston, Texas, on 2026-11-29, cruises to Georgetown, Grand Cayman, Cayman Islands, Montego Bay, Jamaica, Roatan, Honduras, Belize City, Belize, Costa Maya, Mexico and Cozumel, Mexico, starting at 6799.00 per person.

12 Night Caribbean - Western Cruise

Popular Sailings

Miami, Florida

Galveston

Rome (Civitavecchia)

Tampa

Panama City

Explore Departure Ports

Seven Seas Grandeur

Seven Seas Mariner

Seven Seas Splendor

Browse Cruise Ships

Oranjestad, Sint Eustatius

Kralendijk, Bonaire, Dutch Antilles

Willemstad, Curacao

St. George, Bermuda

Castries, St. Lucia

Pointe-a-Pitre, Guadeloupe

Port of Basseterre, St. Kitts, St. Kitts and Nevis

Tortola, B.V.I.

Cozumel, Mexico

Roatan, Honduras

Harvest Caye, Belize

Costa Maya, Mexico

Regent Seven Seas Cruises

Georgetown, Grand Cayman, Cayman Islands

Falmouth, Cornwall, England

Belize City, Belize

Civitavecchia (Rome), Italy

Palma de Mallorca, Spain

Funchal, Madeira, Portugal

Royal Naval Dockyard, Bermuda

San Juan, Puerto Rico

Gustavia, St. Barts

Philipsburg, St. Maarten

Frederikstad, St. Croix

Port Canaveral, Florida

Nassau, Bahamas

Cartagena, Colombia

Panama Canal, Panama

Puntarenas, Costa Rica

Puerto Corinto, Nicaragua

Puerto Quetzal, Guatemala

Acapulco, Mexico

Cabo San Lucas, Mexico

San Diego, California

Los Angeles, California

Puerto Limon, Costa Rica

Colon, Panama

Bridgetown, Barbados

Galveston, Texas

Santo Tomas de Castilla, Guatemala

Montego Bay, Jamaica

Panama City, Panama

Puerto Vallarta, Mexico

Ensenada, Mexico

Central America