Find and compare cruises to Central America in 2026 with Holland America. Get cruise deals, including last-minute deals.

Book cruises to Central America in 2026 with Holland America Online and Save

Cruisebound

16 Night South America Cruise aboard the Oosterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-11-18, cruises to Georgetown, Grand Cayman, Cayman Islands, Panama Canal, Panama, Fuerte Amador, Panama, Fuerte Amador, Panama, Manta (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Callao (Lima), Peru, General San Martin, Peru, Coquimbo (La Serena), Chile and San Antonio, Santiago, Chile, starting at 1669.0 per person.

16 Night South America Cruise

10 Night Caribbean - Western Cruise aboard the Koningsdam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-02-25, cruises to Half Moon Cay (Little San Salvador Island), Bahamas, Falmouth, Jamaica, Georgetown, Grand Cayman, Cayman Islands, Belize City, Belize, Costa Maya, Mexico and Cozumel, Mexico, starting at 1079.0 per person.

10 Night Caribbean - Western Cruise

18 Night Caribbean Cruise aboard the Koningsdam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-02-25, cruises to Half Moon Cay (Little San Salvador Island), Bahamas, Falmouth, Jamaica, Georgetown, Grand Cayman, Cayman Islands, Belize City, Belize, Costa Maya, Mexico, Cozumel, Mexico, Amber Cove, Dominican Republic, San Juan, Puerto Rico, Philipsburg, St. Maarten, St. Thomas, U.S. Virgin Islands and Half Moon Cay (Little San Salvador Island), Bahamas, starting at 1618.0 per person.

18 Night Caribbean Cruise

20 Night Panama Canal Cruise aboard the Eurodam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-04-05, cruises to Cartagena, Colombia, Panama Canal, Panama, Puntarenas, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, Catalina Island, California, Vancouver, British Columbia and Seattle, Washington, starting at 1584.0 per person.

20 Night Panama Canal Cruise

19 Night Panama Canal Cruise aboard the Eurodam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-04-05, cruises to Cartagena, Colombia, Panama Canal, Panama, Puntarenas, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, Catalina Island, California and Vancouver, British Columbia, starting at 1434.0 per person.

19 Night Panama Canal Cruise

15 Night Panama Canal Cruise aboard the Zuiderdam departing from San Diego, California, on 2026-02-27, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Fuerte Amador, Panama, Panama Canal, Panama, Cartagena, Colombia, Half Moon Cay (Little San Salvador Island), Bahamas and Miami, Florida, starting at 1234.0 per person.

15 Night Panama Canal Cruise

17 Night Panama Canal Cruise aboard the Koningsdam departing from San Diego, California, on 2025-11-01, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama Canal, Panama, Port of Oranjestad, Aruba, Caribbean, Half Moon Cay (Little San Salvador Island), Bahamas and Fort Lauderdale (Port Everglades), Florida, starting at 1139.0 per person.

17 Night Panama Canal Cruise

10 Night Caribbean - Western Cruise aboard the Koningsdam departing from Fort Lauderdale (Port Everglades), Florida, on 2026-01-14, cruises to Half Moon Cay (Little San Salvador Island), Bahamas, Falmouth, Jamaica, Georgetown, Grand Cayman, Cayman Islands, Belize City, Belize, Roatan, Honduras and Cozumel, Mexico, starting at 974.0 per person.

17 Night South America Cruise aboard the Oosterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-17, cruises to Georgetown, Grand Cayman, Cayman Islands, Fuerte Amador, Panama, Panama Canal, Panama, Fuerte Amador, Panama, Manta (Quito), Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, Callao (Lima), Peru, Callao (Lima), Peru, General San Martin, Peru, Coquimbo (La Serena), Chile and San Antonio, Santiago, Chile, starting at 974.0 per person.

17 Night South America Cruise

21 Night Panama Canal Cruise aboard the Rotterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-11-28, cruises to Willemstad, Curacao, Port of Oranjestad, Aruba, Caribbean, Port of Oranjestad, Aruba, Caribbean, Half Moon Cay (Little San Salvador Island), Bahamas, Half Moon Cay (Little San Salvador Island), Bahamas, Willemstad, Curacao, Cartagena, Colombia, Gatun Lake, Panama Canal, Panama, Colon, Panama, Panama Canal, Panama, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 881.0 per person.

21 Night Panama Canal Cruise

Popular Sailings

 Fort Lauderdale (Port Everglades)

San Diego, California

Miami, Florida

Vancouver

Seattle

Explore Departure Ports

Koningsdam

Eurodam

Rotterdam

Zuiderdam

Oosterdam

Browse Cruise Ships

Fort Lauderdale (Port Everglades), Florida

Georgetown, Grand Cayman, Cayman Islands

Panama Canal, Panama

Fuerte Amador, Panama

Manta (Quito), Ecuador

Salaverry (Trujillo), Peru

Callao (Lima), Peru

General San Martin, Peru

Coquimbo (La Serena), Chile

San Antonio, Santiago, Chile

Holland America Line

Half Moon Cay, Bahamas (tender Required Wheelchair Access Limited)

Half Moon Cay (Little San Salvador Island), Bahamas

Falmouth, Jamaica

Georgetown, Cayman Islands (tender Required Wheelchair Access Limited)

Belize City, Belize (tender Required Wheelchair Access Limited)

Belize City, Belize

Costa Maya, Mexico

Cozumel, Mexico

Amber Cove, Dominican Republic

San Juan, Puerto Rico

Philipsburg, St. Maarten

St. Thomas, U.S. Virgin Islands

Cartagena, Colombia

Enter Panama Canal Cristobal (cruising Only Transit Times Are Approximate)

Puntarenas (puerto Caldera), Costa Passport Required

Puntarenas, Costa Rica

Acajutla, El Salvador

Puerto Quetzal, Guatemala

Puerto Vallarta, Mexico

Cabo San Lucas, Mexico Tender Required Wheelchair Access Limited

Cabo San Lucas, Mexico

Avalon, California, Us Tender Required Wheelchair Access Limited

Avalon, Catalina Island, California

Vancouver, British Columbia

Seattle, Washington

San Diego, California, Us Boarding Time To Be Assigned

Huatulco, Mexico

Puerto Chiapas, Mexico Times Subject To Tidal Cond

Puerto Chiapas, Mexico

Fuerte Amador, Panama Overnight Times Subject To Canal Transit

Fuerte Amador, Panama Times Subject To Canal Transit

Enter Panama Canal Balboa (cruising Only Transit Times Are Approximate)

Half Moon Cay, Bahamas Tender Required Wheelchair Access Limited

Port of Oranjestad, Aruba, Caribbean

Roatan, Honduras

Georgetown, Cayman Islands Tender Required Wheelchair Access Limited

Coquimbo (la Serena), Chile Visa Req For Some

San Antonio (santiago), Chile Visa Req For Some

Willemstad, Curacao

Gatun Lake, Panama (cruising Only Shore Excursion Guests Only)

Gatun Lake, Panama Canal, Panama

Colon, Panama

Cruising Panama Canal And Gatun Lak (cruising Only)

Puerto Limon (san Jose), Costa Rica (passport Required)