Find and compare cruises from Palermo, Sicily, Italy on Cruisebound. Search the best cruise deals, including last-minute deals.

Book cruises from Palermo, Sicily, Italy in April Online And Save

Cruisebound

23 Night Mediterranean Cruise aboard the MSC Seaside departing from Palermo, Sicily, Italy, on 2025-10-24, cruises to Naples, Italy, Livorno (Florence/Pisa), Italy, Marseille, France, Barcelona, Spain, Valencia, Spain, Casablanca, Morocco, Bridgetown, Barbados, St. Georges, Grenada, West Indies, Philipsburg, St. Maarten, San Juan, Puerto Rico and Miami, Florida, starting at 1759.0 per person.

23 Night Mediterranean Cruise

7 Night Mediterranean Cruise aboard the Costa Toscana departing from Palermo, Sicily, Italy, on 2025-10-24, cruises to Civitavecchia (Rome), Italy, Cetacean Sanctuary, Savona (Genoa), Italy, Marseille, France, Barcelona, Spain and Palma de Mallorca, Spain, starting at 906.0 per person.

7 Night Mediterranean Cruise

16 Night Grand Voyage Cruise aboard the MSC Lirica departing from Palermo, Sicily, Italy, on 2025-11-12, cruises to Valencia, Spain, Santa Cruz de Tenerife, Canary Islands, Recife, Brazil, Buzios, Brazil, Rio de Janeiro, Brazil and Santos (Sao Paulo), Brazil, starting at 979.0 per person.

16 Night Grand Voyage Cruise

7 Night Mediterranean - Western Cruise aboard the MSC Magnifica departing from Palermo, Sicily, Italy, on 2025-05-21, cruises to Valletta, Malta, Barcelona, Spain, Marseille, France, La Spezia (Cinque Terre), Italy and Naples, Italy, starting at 686.0 per person.

7 Night Mediterranean - Western Cruise

7 Night Mediterranean Cruise aboard the Costa Toscana departing from Palermo, Sicily, Italy, on 2025-10-17, cruises to Civitavecchia (Rome), Italy, Cetacean Sanctuary, Savona (Genoa), Italy, Marseille, France, Barcelona, Spain and Palma de Mallorca, Spain, starting at 896.22 per person.

7 Night Mediterranean - Western Cruise aboard the MSC Splendida departing from Palermo, Sicily, Italy, on 2025-12-10, cruises to La Goulette, Tunisia, Barcelona, Spain, Marseille, France, Genoa, Italy and Naples, Italy, starting at 609.0 per person.

5 Night Mediterranean - Western Cruise aboard the MSC Grandiosa departing from Palermo, Sicily, Italy, on 2025-11-10, cruises to Ibiza, Spain, Valencia, Spain, Marseille, France and Genoa, Italy, starting at 539.0 per person.

5 Night Mediterranean - Western Cruise

6 Night Mediterranean Cruise aboard the Costa Fascinosa departing from Palermo, Sicily, Italy, on 2025-09-28, cruises to Naples, Italy, La Goulette, Tunisia, Naples, Italy and Genoa, Italy, starting at 520.05 per person.

6 Night Mediterranean Cruise

4 Night Mediterranean Cruise aboard the Costa Fascinosa departing from Palermo, Sicily, Italy, on 2025-09-24, cruises to Naples, Italy and Valletta, Malta, starting at 439.0 per person.

4 Night Mediterranean Cruise

3 Night Mediterranean - Western Cruise aboard the MSC Magnifica departing from Palermo, Sicily, Italy, on 2025-10-01, cruises to Valletta, Malta and Barcelona, Spain, starting at 439.0 per person.

3 Night Mediterranean - Western Cruise

Popular Sailings

Costa Cruises

MSC Cruises

Browse Cruise Lines

Europe

Mediterranean

Iberian Peninsula

Explore Destinations

Palermo, Sicily, Italy

Naples, Italy

Livorno (Florence/Pisa), Italy

Marseille, France

Barcelona, Spain

Valencia, Spain

Casablanca, Morocco

Bridgetown, Barbados

St. Georges, Grenada, West Indies

Philipsburg, St. Maarten

San Juan, Puerto Rico

Miami, Florida

MSC Seaside

Civitavecchia (Rome), Italy

Cetacean Sanctuary

Savona (Genoa), Italy

Palma de Mallorca, Spain

Costa Cruise Lines

Costa Toscana

Santa Cruz De Tenerife (canary Is.) Spain

Santa Cruz de Tenerife, Canary Islands

Recife, Brazil

Buzios, Brazil

Rio de Janeiro, Brazil

Santos (Sao Paulo), Brazil

MSC Lirica

Valletta, Malta

La Spezia (Cinque Terre), Italy

MSC Magnifica

La Goulette, Tunisia

Genoa, Italy

MSC Splendida

Ibiza, Spain

MSC Grandiosa

Costa Fascinosa