Find and book cruises from Colon, Panama online. Search the best cruise deals, including last-minute deals.

Book Cruises From Colon Panama Online And Save

Cruisebound

12 Night Panama Canal Cruise aboard the Regatta departing from Colon, Panama, on 2025-11-14, cruises to Panama Canal Daylight Transit, Puntarenas, Costa Rica, Puerto Corinto, Nicaragua, Puerto Quetzal, Guatemala, Acapulco, Mexico, Cabo San Lucas, Mexico, Ensenada, Mexico and Los Angeles, California, starting at 2590.0 per person.

12 Night Panama Canal Cruise

7 Night Southern Caribbean Holiday aboard the Jewel of the Seas departing from Colon, Panama, on 2026-12-26, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 961.5 per person.

7 Night Southern Caribbean Holiday

8 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-12, cruises to Cartagena, Colombia, Kralendijk, Bonaire, Dutch Antilles, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 1148.5 per person.

8 Night Southern Caribbean Cruise

7 Night Southern Caribbean Cruise aboard the Jewel of the Seas departing from Colon, Panama, on 2026-09-12, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 731.5 per person.

7 Night Southern Caribbean Cruise

7 Night Southern Caribbean Holiday aboard the Jewel of the Seas departing from Colon, Panama, on 2026-12-19, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Kralendijk, Bonaire, Dutch Antilles, starting at 921.0 per person.

10 Night Panama Canal Westward Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2026-04-25, cruises to Panama Canal, Panama, Puntarenas, Costa Rica, Santa Cruz Huatulco, Mexico, Puerto Vallarta, Mexico and Los Angeles, California, starting at 851.0 per person.

10 Night Panama Canal Westward Cruise

6 Night Southern Caribbean Cruise aboard the Serenade of the Seas departing from Colon, Panama, on 2025-12-06, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 828.5 per person.

6 Night Southern Caribbean Cruise

7 Night Southern Caribbean Cruise aboard the Jewel of the Seas departing from Colon, Panama, on 2026-09-19, cruises to Cartagena, Colombia, Port of Oranjestad, Aruba, Caribbean and Willemstad, Curacao, starting at 731.5 per person.

Popular Sailings

Royal Caribbean International

Oceania Cruises

Browse Cruise Lines

Central America

Panama Canal

Caribbean

South America

Pacific

Explore Destinations

Colon, Panama

Panama Canal Daylight Transit

Puntarenas, Costa Rica

Puerto Corinto, Nicaragua

Puerto Quetzal, Guatemala

Acapulco, Mexico

Cabo San Lucas, Mexico

Ensenada, Mexico

Los Angeles, California

Regatta

Cartagena, Colombia

Port of Oranjestad, Aruba, Caribbean

Willemstad, Curacao

Jewel of the Seas

Kralendijk, Bonaire, Dutch Antilles

Serenade of the Seas

Panama Canal, Panama

Santa Cruz Huatulco, Mexico

Puerto Vallarta, Mexico