Find and compare 14 night cruises to South America in 2024 on Cruisebound. Book cruises online with no fees.

Book 14 night cruises to South America in 2024 Online and Save

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16 Night Transcanal Cruise aboard the Island Princess departing from San Francisco, California, on 2025-12-07, cruises to Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit Historic Locks, Cartagena, Colombia and Fort Lauderdale (Port Everglades), Florida, starting at 728.0 per person.

16 Night Transcanal Cruise

7 Night Galapagos Inner Loop Cruise aboard the Celebrity Flora departing from Isla Baltra, Galapagos Islands, on 2025-09-14, cruises to Isla Rabida, Galapagos Islands, Isla Santiago (Puerto Egas), Galapagos Islands, Isla Isabela (Caleta Tagus), Galapagos Islands, Elizabeth Bay (Isabela), Galapagos Islands, Isla Bartolome, Galapagos Islands, Isla Santiago (Puerto Egas), Galapagos Islands, Daphne Island (galapagos), Las Bachas, Isla North Seymour, Galapagos Islands, Punta Pitt, Galapagos Island, Puerto Baquerizo, Cristobal, Galapagos Islands and Puerto Ayora, Galapagos Islands, starting at 7872.0 per person.

7 Night Galapagos Inner Loop Cruise

10 Night Mediterranean - Western Cruise aboard the Seven Seas Voyager departing from Lisbon, Portugal, on 2025-09-14, cruises to Cadiz (Seville), Spain, Malaga, Spain, Cartagena, Colombia, Alicante, Spain, Mahon, Minorca, Spain, Palamos, Spain, Sete, France and Barcelona, Spain, starting at 7399.0 per person.

10 Night Mediterranean - Western Cruise

6 Night South America Cruise aboard the MSC Armonia departing from Rio de Janeiro, Brazil, on 2026-01-04, cruises to Buzios, Brazil, Bahia de Salvador, Brazil and Ilheus(Bahia), Brazil, starting at 679.0 per person.

6 Night South America Cruise

7 Night Galapagos Outer Loop Cruise aboard the Celebrity Flora departing from Isla Baltra, Galapagos Islands, on 2025-07-27, cruises to Punta Suarez, Galapagos Islands, Espanola (Hood) Island, Ecuador, Cormorant Point (Floreana), Galapagos Islands, Galapagos Islands, Ecuador, Galapagos Islands, Ecuador, Isla Isabela (Caleta Tagus), Galapagos Islands, Galapagos Islands, Ecuador, Punta Espinoza, Galapagos Islands, Galapagos Islands, Ecuador, Daphne Island (galapagos), Dragon Hill (santa Cruz), Galapagos Islands and Puerto Ayora, Galapagos Islands, starting at 7488.0 per person.

7 Night Galapagos Outer Loop Cruise

10 Night Mediterranean Cruise aboard the Nautica departing from Barcelona, Spain, on 2026-06-01, cruises to Villefranche, France, Florence, Italy, Civitavecchia (Rome), Italy, Ibiza, Spain, Cartagena, Colombia, Malaga, Spain, Seville, Spain, Lisbon, Portugal and Lisbon, Portugal, starting at 3199.0 per person.

10 Night Mediterranean Cruise

7 Night South America Cruise aboard the MSC Preziosa departing from Buenos Aires, Argentina, on 2026-03-19, cruises to Santos (Sao Paulo), Brazil, Camboriú, Brazil and Punta del Este, Uruguay, starting at 638.0 per person.

7 Night South America Cruise

5 Night Grand Voyage Cruise aboard the MSC Preziosa departing from Santos (Sao Paulo), Brazil, on 2026-04-02, cruises to Rio de Janeiro, Brazil, Ilheus(Bahia), Brazil, Bahia de Salvador, Brazil and Maceio, Brazil, starting at 589.0 per person.

5 Night Grand Voyage Cruise

8 Night Argentina, Brazil & Uruguay aboard the Celebrity Equinox departing from Buenos Aires, Argentina, on 2026-03-14, cruises to Punta del Este, Uruguay, Montevideo, Uruguay, Ilhabela, Brazil, Rio de Janeiro, Brazil, Rio de Janeiro, Brazil and Santos (Sao Paulo), Brazil, starting at 548.5 per person.

8 Night Argentina, Brazil & Uruguay

12 Night Panama Canal Cruise aboard the Rotterdam departing from Fort Lauderdale (Port Everglades), Florida, on 2025-12-07, cruises to Half Moon Cay (Little San Salvador Island), Bahamas, Willemstad, Curacao, Cartagena, Colombia, Colon, Panama, Gatun Lake, Panama Canal, Panama, Panama Canal, Panama, Puerto Limon, Costa Rica and Georgetown, Grand Cayman, Cayman Islands, starting at 529.0 per person.

12 Night Panama Canal Cruise

Popular Sailings

San Francisco, California

Puerto Vallarta, Mexico

Puerto Quetzal, Guatemala

Puntarenas, Costa Rica

Fuerte Amador, Panama

Panama Canal Full Transit Historic Locks

Cartagena, Colombia

Fort Lauderdale (Port Everglades), Florida

Princess Cruises

Island Princess

Isla Baltra, Galapagos Islands

Isla Rabida, Galapagos Islands

Isla Santiago (Puerto Egas), Galapagos Islands

Isla Isabela (Caleta Tagus), Galapagos Islands

Elizabeth Bay (Isabela), Galapagos Islands

Isla Bartolome, Galapagos Islands

Daphne Island (galapagos)

Las Bachas

Isla North Seymour, Galapagos Islands

Punta Pitt, Galapagos Island

Puerto Baquerizo, Cristobal, Galapagos Islands

Puerto Ayora, Galapagos Islands

Celebrity Cruises

Celebrity Flora

Lisbon, Portugal

Cadiz (Seville), Spain

Malaga, Spain

Alicante, Spain

Mahon, Minorca, Spain

Palamos, Spain

Sete, France

Barcelona, Spain

Regent Seven Seas Cruises

Seven Seas Voyager

Rio de Janeiro, Brazil

Buzios, Brazil

Bahia de Salvador, Brazil

Ilheus(Bahia), Brazil

MSC Cruises

MSC Armonia

Punta Suarez, Galapagos Islands

Espanola (Hood) Island, Ecuador

Cormorant Point (Floreana), Galapagos Islands

Galapagos Islands, Ecuador

Punta Espinoza, Galapagos Islands

Dragon Hill (santa Cruz), Galapagos Islands

Villefranche, France

Florence, Italy

Civitavecchia (Rome), Italy

Ibiza, Spain

Seville, Spain

Oceania Cruises

Nautica

Buenos Aires, Argentina

Santos (Sao Paulo), Brazil

Camboriú, Brazil

Punta del Este, Uruguay

MSC Preziosa

Maceio, Brazil

Montevideo, Uruguay

Ilhabela, Brazil

Celebrity Equinox

Half Moon Cay, Bahamas (tender Required Wheelchair Access Limited)

Half Moon Cay (Little San Salvador Island), Bahamas

Willemstad, Curacao

Colon, Panama

Gatun Lake, Panama (cruising Only Shore Excursion Guests Only)

Gatun Lake, Panama Canal, Panama

Enter Panama Canal Cristobal (cruising Only Transit Times Are Approximate)

Panama Canal, Panama

Cruising Panama Canal And Gatun Lak (cruising Only)

Puerto Limon (san Jose), Costa Rica (passport Required)

Puerto Limon, Costa Rica

Georgetown, Cayman Islands (tender Required Wheelchair Access Limited)

Georgetown, Grand Cayman, Cayman Islands

Holland America Line

Rotterdam

South America