Find and book cruises from San Diego, California online. Search the best cruise deals, including last-minute deals.

Book Cruises From San Diego California Online And Save

Cruisebound

Royal Caribbean International

7 Night Ensenada, Cabo & La Paz Cruise aboard the Serenade of the Seas departing from San Diego, California, on 2026-10-25, cruises to La Paz, Mexico, Cabo San Lucas, Mexico and Ensenada, Mexico, starting at 496.5 per person.

7 Night Ensenada, Cabo & La Paz Cruise

7 Night Cabo, Mazatlan & La Paz Cruise aboard the Serenade of the Seas departing from San Diego, California, on 2026-11-22, cruises to Cabo San Lucas, Mexico, La Paz, Mexico and Mazatlan, Mexico, starting at 686.0 per person.

7 Night Cabo, Mazatlan & La Paz Cruise

Holland America Line

10 Night Mexico Cruise aboard the Nieuw Amsterdam departing from San Diego, California, on 2025-11-29, cruises to Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Mazatlan, Mexico and Puerto Vallarta, Mexico, starting at 749.0 per person.

10 Night Mexico Cruise

Norwegian Cruise Line

8 Night Mexican Riviera aboard the Norwegian Jade departing from San Diego, California, on 2025-10-18, cruises to Cabo San Lucas, Mexico, La Paz, Mexico, Mazatlan, Mexico and Puerto Vallarta, Mexico, starting at 439.33000000000004 per person.

8 Night Mexican Riviera

7 Night Mexico Cruise aboard the Nieuw Amsterdam departing from San Diego, California, on 2025-11-15, cruises to Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico and Loreto, Mexico, starting at 599.0 per person.

7 Night Mexico Cruise

7 Night U. S. Pacific Coast Cruise aboard the Nieuw Amsterdam departing from San Diego, California, on 2025-11-01, cruises to Avalon, Catalina Island, California, San Francisco, California, San Francisco, California and Ensenada, Mexico, starting at 368.0 per person.

7 Night U. S. Pacific Coast Cruise

5 Night Mexican Riviera aboard the Norwegian Jade departing from San Diego, California, on 2026-02-07, cruises to Cabo San Lucas, Mexico and Cabo San Lucas, Mexico, starting at 339.0 per person.

5 Night Mexican Riviera

5 Night U. S. Pacific Coast Cruise aboard the Koningsdam departing from San Diego, California, on 2026-04-27, cruises to San Francisco, California and Vancouver, British Columbia, starting at 324.0 per person.

5 Night U. S. Pacific Coast Cruise

4 Night U. S. Pacific Coast Cruise aboard the Zaandam departing from San Diego, California, on 2026-05-02, cruises to Victoria, British Columbia and Vancouver, British Columbia, starting at 289.0 per person.

4 Night U. S. Pacific Coast Cruise

4 Night Catalina & Ensenada Cruise aboard the Serenade of the Seas departing from San Diego, California, on 2027-02-21, cruises to Avalon, Catalina Island, California and Ensenada, Mexico, starting at 276.0 per person.

4 Night Catalina & Ensenada Cruise

Popular Sailings

Disney Cruise Line

Azamara

Browse Cruise Lines

North America

Mexico

Pacific

Caribbean

Central America

Explore Destinations

San Diego, California

La Paz, Mexico

Cabo San Lucas, Mexico

Ensenada, Mexico

Serenade of the Seas

Mazatlan, Mexico

San Diego, California, Us (boarding Time To Be Assigned)

Cabo San Lucas, Mexico (tender Required Wheelchair Access Limited)

Pichilingue (La Paz), Mexico

Loreto, Mexico (tender Required Wheelchair Access Limited)

Loreto, Mexico

Puerto Vallarta, Mexico

Nieuw Amsterdam

Norwegian Jade

Avalon, California, Us (tender Required Wheelchair Access Limited)

Avalon, Catalina Island, California

San Francisco, California, Us (overnight)